Mechanosensitivity of human oligodendrocytes

Espinosa-Hoyos D., Burstein S.R., Cha J., Jain T., Nijsure M., Jagielska A., Fossati V., Van Vliet K.J.

Frontiers in Cellular Neuroscience 14 (2020). DOI: 10.3389/fncel.2020.00222


Mechanical regulation of oligodendrocyte biology

Makhija E., Espinosa-Hoyos D., Jagielska A., Van Vliet K.J.

Neuroscience Letters 717 (2020). DOI: 10.1016/j.neulet.2019.134673


High-resolution imaging of nuclear dynamics in live cells under uniaxial tensile strain

Makhija E., Jagielska A., Van Vliet K.J.

Journal of Visualized Experiments 148 (2019). DOI: 10.3791/59474

Acute but not inherited demyelination in mouse models leads to brain tissue stiffness changes

Eberle D., Fodelianaki G., Kurth T., Jagielska A., Moellmert S., Ulbricht E., Wagner K., Taubenberger A. V., Traeber N., Escolano J.C., Franklin R. M., Van Vliet K.J., Guck J.

bioRxiv (2019). DOI: 10.1101/449603

Emergent heterogeneity in putative mesenchymal stem cell colonies: Single-cell time lapsed analysis

Rennerfeldt D.A., Raminhos J.S., Leff S.M., Manning P., Van Vliet K.J.

PLoS ONE 14 (2019). DOI: 10.1371/journal.pone.0213452


Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome

Liu F.D., Tam K., Pishesha N., Poon Z., Van Vliet, K.J.

Stem Cell Research & Therapy 9 (2018). DOI: 10.1186/s13287-018-0982-2


Mechanical strain alters cellular and nuclear dynamics at early stages of oligodendrocyte differentiation

Makhija E., Jagielska A.,  Zhu L., Bost A., Ong W., Chew S.Y., Shivashankar G.V., Van Vliet K.J.

Frontiers in Cellular Neuroscience 12 (2018). DOI: 10.3389/fncel.2018.00059


Engineered 3D-printed artificial axons

Espinosa-Hoyos D., Jagielska A., Homan K.A., Du H., Busbee T., Anderson D.G., Fang N.X., Lewis J.A., Van Vliet K.J.

Scientific Reports 8 (2018). DOI: 10.1038/s41598-017-18744-6



Material viscoelastic properties modulate the mesenchymal stem cell secretome for applications in hematopoietic recovery

Liu F.D., Pishesha N., Poon Z., Kaushik T., Van Vliet K.J.

ACS Biomaterials Science & Engineering 3 (2017). DOI: : 10.1021/acsbiomaterials.7b00644


Poly(HDDA)-based polymers for microfabrication and mechanobiology

Espinosa-Hoyos D., Du H., Fang N.X., Van Vliet K.J.

MRS Advances 2 (2017). DOI: 10.1557/adv.2017.57


Mechanical strain promotes oligodendrocyte differentiation by global changes of gene expression

Jagielska A., Lowe A.L., Makhija E., Wroblewska L., Guck J., Franklin R.J.M., Shivashankar G.V., Van Vliet K.J.

Frontiers in Cellular Neuroscience 11 (2017). DOI: 10.3389/fncel.2017.00093



Static mechanical strain induces capillary endothelial cell cycle re-entry and sprouting

Zeiger A.S., Liu F.D., Durham J.T., Jagielska A., Mahmoodian R., Van Vliet K.J., Herman I.M.

Physical Biology 13 (2016). DOI: 10.3389/fncel.2020.00222


When colonies are not clones: Evidence and implications of intracolony heterogeneity in mesenchymal stem cells

Rennerfeldt D.A., Van Vliet K.J.

Stem Cells 34 (2016). DOI: 10.1002/stem.2296



Bone marrow regeneration promoted by biophysically sorted osteoprogenitors from mesenchymal stromal cells

Poon Z., Lee W.C., Guo G., Lim C.T., Han J., Van Vliet, K.J.

Stem Cells Translational Medicine 4 (2015). DOI: 10.5966/sctm.2014-0154



Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency

Lee W.C., Shi H., Poon Z., Kaushik T., Nyan L.M., Chan J., Shivashankar G., Lim C.T., Han J., Van Vliet K.J.

Proceedings of the National Academy of Sciences 111 (2014). DOI: 10.1073/pnas.1402306111


Chemoenvironmental modulators of fluidity in the suspended biological cell

Maloney J.M., Van Vliet K.J.

Soft Matter 10 (2014). DOI: 10.1039/c4sm00743c


Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance

Martinelli R., Zeiger A.S., Whitfield M., Sciuto T.E., Dvorak A.M., Van Vliet K.J., Greenwood J., Carman C.V.

Journal of Cell Science 127 (2014). DOI: 10.1242/jcs.148619



Onset of heterogeneity in culture-expanded bone marrow stromal cells

Whitfield M.J., Lee W.C.J., Van Vliet K.J.

Stem Cell Research 11 (2013). DOI: 10.1016/j.scr.2013.09.004


Mechanical fluidity of fully suspended biological cells

Maloney J.M., Lehnhardt E., Long A.F., Van Vliet K.J.

Biophysical Journey 105 (2013). DOI: 10.1016/j.bpj.2013.08.040


Extracellular acidic pH inhibits oligodendrocyte precursor viability, migration, and differentiation

Jagielska A., Wilhite K.D., Van Vliet K.J.

PLoS One 8 (2013). DOI: 10.1371/journal.pone.0076048


Quantifying cell-to-cell variation in power-law rheology

Cai P., Mizutani Y., Tsuchiya M., Maloney J.M., Fabry B., Van Vliet, K.J, Okajima T.

Biophysical Journal 105 (2013). DOI: 10.1016/j.bpj.2013.07.035


Why the dish makes a difference: Quantitative comparison of polystyrene culture surfaces

Zeiger A.S., Hinton B., Van Vliet K.J.

Acta Biomaterialia 9 (2013). DOI: 10.1016/j.actbio.2013.02.035


Directional cell migration in an extracellular pH gradient: A model study with an engineered cell line and primary microvascular endothelial cells

Paradise R.K., Whitfield M.J., Lauffenburger D.A., Van Vliet K.J.

Experimental Cell Research 319 (2013). DOI: 10.1016/j.yexcr.2012.11.006



Mechanical environment modulates biological properties of oligodendrocyte progenitor cells

Jagielska A.J., Norman A.L., Whyte G., Van Vliet K.J., Guck J., Franklin R.M.J

Stem Cells and Development 21 (2012). DOI: 10.1089/scd.2012.0189


Macromolecular crowding directs extracellular matrix organization and mesenchymal stem cell behavior

Zeiger A.S., Loe F.C., Li R., Raghunath M., Van Vliet K.J.

PLoS One 7 (2012). DOI: 10.1371/journal.pone.0037904



High-throughput cell cycle synchronization using inertial forces in spiral microchannels

Lee W.C., Bhagat A.A., Huang S., Van Vliet K.J., Han J., Lim C.T.

Lab on a Chip 11 (2011). DOI: 10.1039/c0lc00579g


Acidic extracellular pH promotes activation of integrin αvβ3

Paradise R.K., Lauffenburger D.A., Van Vliet K.J.

PLoS One 6 (2011). DOI: 10.1371/journal.pone.0015746


Studying cell rolling trajectories on asymmetric receptor patterns

Lee C.H., Bose S., Van Vliet K.J., Karp J., Karnik R.

Journal of Visualized Experiments 48 (2011). DOI: 10.3791/2640


Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness

Peyton S., Kalcioglu Z.I., Runkle A., Van Vliet K.J., Lauffenburger D.A., Griffith, L.J

Biotechnology and Bioengineering 108 (2011). DOI: 10.1002/bit.23027

Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays

Williams C., Mehta G., Zeiger A.S., Van Vliet K.J., Griffith L.J.

Tissue Engineering Part A 7 (2011). DOI: 10.1089/ten.tea.2010.0398

Examining lateral displacement of HL60 cells rolling on asymmetric P-selectin patterns

Lee C.H., Van Vliet K.J., Karp J., Karnik R.

Langmuir 27 (2011). DOI: 10.1021/la102871m


The anti-angiogenic peptide, Loop 6, binds IGF-IR

Fernandez C.A., Roy R., Lee S., Yang J., Panigrahy D., Van Vliet K.J., Moses M.A.

Journal of Biological Chemistry 285 (2010). DOI: 10.1074/jbc.M110.166439

Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness

Kotecki M., Zeiger A.S., Van Vliet K.J., Herman I.M.

Microvascular Research 80 (2010). DOI: 10.1016/j.mvr.2010.07.012

Mesenchymal stem cell mechanics from the attached to the suspended state

Maloney J.M., Nikova D., Lautenschlager F., Clarke E., Langer R.L., Guck J., Van Vliet K.J.

Biophysical Journal 99 (2010). DOI: 10.1016/j.bpj.2010.08.052

Pericyte actomyosin-mediated contraction at the cell-material interface can modulate the microvascular niche

Lee S., Zeiger A., Maloney J.M., Kotecki M., Van Vliet K.J., Herman I.M.

Journal of Physics: Condensed Matter 22 (2010). DOI: 10.1088/0953-8984/22/19/194115

Genetically engineered phage fibers and coatings for antibacterial applications

Mao J.Y., Belcher A.M., Van Vliet K.J.

Advanced Functional Materials 20 (2010). DOI: 10.1002/adfm.200900782